PACKING AVAILABLE – 15 ALUALU
Product Form: Tablet
Key Ingredients:
- Letrozole 2.5 mg Tablet
About Composition
Letrozole is a highly potent and selective AI (Aromatase Inhibitor) that inhibits the enzyme activity of intracellular aromatase at the major sites where it is found, resulting in almost complete suppression of whole body aromatization. By effectively blocking estrogen synthesis, letrozole inhibits the growth or induces the regression of hormone-responsive breast tumors in vivo. Estrogen is implicated as a major risk factor in the majority of breast cancers; therefore, use of the most potent AI is a logical treatment strategy. Because estrogen contributes to the promotion and progression of breast cancer, a greater understanding of the role of estrogen in breast cancer has led to therapeutic strategies targeting estrogen synthesis, the estrogen receptor, and intracellular signaling pathways. The enzyme aromatase catalyses the final step in estrogen biosynthesis and was identified as an attractive target for selective inhibition. Modern third-generation aromatase inhibitors (AIs) effectively block the production of estrogen without exerting effects on other steroidogenic pathways. The discovery of letrozole has achieved the goal of discovering a highly potent and totally selective AI. Letrozole has greater potency than other AIs, including anastrozole, exemestane, formestane, and aminoglutethimide. Moreover, letrozole produces near complete inhibition of aromatase in peripheral tissues and is associated with greater suppression of estrogen than is achieved with other AIs.
Letrozole, an aromatase inhibitor that blocks estrogen synthesis by inhibiting the final step of the estrogen biosynthetic pathway, has been used in the applications of a wide range of infertility settings. It has been more than 20 years since the initial clinical trial of letrozole for ovulation induction. Letrozole inhibits the aromatase activity by more than 99% and endogenous estrogen synthesis by 97%-99%. The mechanisms of letrozole for OI remain unclear. However, it has been proposed that it may act through both centrally and peripherally mechanisms. Centrally, letrozole dramatically lowers the estrogen level, which prevents its negative feedback on the hypothalamic-pituitary-gonad (HPO) axis. Peripherally, as the conversion of androgen substrates to estrogen is inhibited, the temporary accumulation of intraovarian androgens may increase follicular sensitivity through amplification of FSH receptor gene expression. Also, androgens accumulation in the follicle may stimulate insulin-like growth factor 1 (IGF-1) and other endocrine and paracrine factors, which may synergize with FSH to promote folliculogenesis.
Benefits
In Treatment of Breast cancer
Follizole Tablet relieves the symptoms of breast cancer such as breast lumps, bloody discharge from the nipple, or changes in the shape or texture of the breast. It works by altering the production of those hormones in the body that are essential for the growth and spread of breast cancer. It may also interact with other hormones or have a direct effect on cancer to stop its growth.
In Treatment of Infertility due to anovulation
Follizole Tablet helps in the normal development of an egg in a woman’s ovary (female reproductive organ) and stimulates the release of the egg during a process called ovulation. This helps to treat infertility in women. This increases the chance of a successful pregnancy.
Storage
Store in a cool and dry place away from sunlight, moisture and heat.
Side Effects
- Nervousness
- cough
- dizziness or lightheadedness
- fainting
- increased sweating
- nausea
- pain in the chest, groin, or legs, especially the calves
- slurred speech
- vaginal bleeding
- vision changes
- Back pain
- hot flashes (sudden sweating and feeling of warmth)
- joint pain
- muscle pain
- breast pain
- chest pain
- chills, fever, or flu-like symptoms